The powerpuff girls once again get into a fight with the MaleficMage girls and get into an argument of who's life is the harder one. Of being a superhero or a supervillain. Therefore the powerpuffs and maleficmages switch places by disguising themselves as each other to figure out how hard the other's life is. Can the girls become 3 new people who's lives and personalities are reflections of them?
Meanwhile the maleficmage girls disguised as the powerpuffs fight Mojo Jojo.